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. 2019 Mar 21;9:5012. doi: 10.1038/s41598-019-41380-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cdk5 knockdown reduces glioma cell viability and induces autophagy. (A) Effect of Cdk5 knockdown on percent survival of U87 and U373 cell lines using specific SiRNA. Cells were treated with indicated concentrations of Cdk5 specific SiRNA and control SiRNA. Cell viability was assessed by MTT assay 48 h post transfection. (B) Immuno-blots depicting the knockdown of Cdk5 protein and increased expression of LC3B upon Cdk5 knockdown in U87 and U373 cells. Whole cell lysates prepared from U87 and U373 cells, 48 h post transfection were immune blotted for the expression levels of Cdk5, LC3B and beta actin. (C) Immuno blot depicting changes in the expression of pCdk5 upon treatment with Rapamycin (Rap) in U87 and U373 cells. *p < 0.05, **p < 0.001, ***p < 0.0001.