Table 2.
Predicted regulatory genes and SNPs for the risk of gout in lymphocytes.
| Gene | SNP | Proximity | Location | Result in Discovery | Result in Follow-up | ||
|---|---|---|---|---|---|---|---|
| LBF | P* | LBF | P | ||||
| PKD2 | 4q22.1 | 6.89 | 1.08e-05 | 6.93 | 8.98e-06 | ||
| rs4148155 | cis | chr4:89273691 | 7.02 | 2.00e-05 | 7.02 | 2.00e-05 | |
| NUDT9 | 4q22.1 | 6.41 | 2.87e-05 | 5.79 | 6.29e-05 | ||
| rs10516801 | cis | 5.62 | 8.00e-05 | 6.02 | 8.00e-05 | ||
| NAP1L5 | 4q22.1 | 5.54 | 9.52e-05 | 6.10 | 4.67e-05 | ||
| rs4148155 | cis | chr4:89273691 | 5.62 | 2.00e-04 | 5.62 | 2.00e-04 | |
| BRE | 2p23.2 | 5.87 | 6.11e-05 | 2.57 | 5.76e-03 | ||
| rs4148155 | trans | chr4:89273691 | 2.66 | 9.90e-06 | 2.66 | 9.90e-06 | |
| rs4129943 | trans | chr2:241402488 | 2.25 | 2.00e-06 | −0.102 | 2.00e-06 | |
*The gene p-vaule refers to the Sherlock p value, but the SNP p-value refers to the eQTL P value.