Figure 4.

Relative contact frequencies of individual residues in the mixed orientation CG simulations at L/T = 28:1. (A) Contact frequency was calculated as the fraction of snapshots in which a residue was involved in intertetramer contact and then normalized by the highest value of all residues. (B) The M2TM surface colored according to residue contact frequency, from the maximal 1 (blue) to 0.5 (pink) to 0 (white). In the side view on the left, five residues with the highest contact frequencies are labeled. In the top view on the right, an example of antiparallel interactions of two tetramers is shown in a corner-to-face pose, illustrating shape complementarity.