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. 2019 Mar 15;9:150. doi: 10.3389/fonc.2019.00150

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Copyright © 2019 Huang, Wei, Huang, Zhang, Zhang, Jiang, Yang, Wang, Jin, Wang, Xing, Yuan, Li, He, Shi and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TF promotes the growth of HCC by activating both ERK and AKT signaling pathways. (A) Western blot analysis of the protein expressions in the indicated cells. SK-HEP1 shTF-Vector and SK-HEP1 shTF-TF cells were treated with/without U0126 and LY294002 at the concentration of 10 μM for 24 h. (B–D) Western blot and (E) MTT assay analysis of the protein expressions and cell growth. Error bars, mean ± SD. *p < 0.05 (two-tailed Student's t-test E).