Figure 7.

Model of both Direct and Indirect Roles of Y14 in Genome Stability

Y14 maintains proper expression of DDR factors and prevents the formation of co-transcriptional R-loops likely through its role as an EJC factor (left). Y14 may directly participate in DNA damage repair via its RNA-mediated interaction with Ku and other DDR factors. Upon DNA damage, Y14 promotes Ku and DDR factors to DNA lesion and modulates Ku ubiquitination (ubi) and release after repair (right). Y14 deficiency impairs NHEJ.