Table 3. Multivariable association of risk factors including GRS with AF recurrence after catheter ablation.
| Variable | Recurrence | |||
|---|---|---|---|---|
| Unadjusted univariable HR (95% CI) | p value | Adjusted HR* (95% CI) | p value | |
| GRS | 1.166 (1.066–1.275) | 0.001 | 1.132 (1.034–1.240) | 0.007 |
| Age | 0.995 (0.981–1.009) | 0.513 | 0.996 (0.980–1.012) | 0.589 |
| Sex (male) | 1.406 (0.969–2.041) | 0.073 | 1.182 (0.792–1.764) | 0.413 |
| BMI | 0.978 (0.924–1.034) | 0.430 | 0.909 (0.851–0.971) | 0.005 |
| Persistent AF | 1.549 (1.144–2.098) | 0.005 | 1.062 (0.754–1.496) | 0.730 |
| Hypertension | 0.843 (0.620–1.145) | 0.274 | 0.896 (0.644–1.247) | 0.515 |
| DM | 0.867 (0.558–1.346) | 0.525 | 0.966 (0.615–1.517) | 0.881 |
| Heart failure | 1.572 (1.053–2.345) | 0.027 | 1.160 (0.759–1.773) | 0.492 |
| Previous stroke | 1.606 (0.912–2.830) | 0.101 | 1.680 (0.946–2.984) | 0.077 |
| LA diameter | 1.063 (1.041–1.086) | <0.001 | 1.060 (1.034–1.087) | <0.001 |
| LVEF | 0.951 (0.936–0.967) | <0.001 | 0.967 (0.949–0.984) | <0.001 |
AF = atrial fibrillation; BMI = body mass index; CI = confidence interval; DM = diabetes mellitus, GRS = genetic risk score; HR = hazard ratio; LA = left atrium; LVEF = left ventricular ejection fraction; SNP = single nucleotide polymorphism.
*The associations were tested with a Cox proportional hazards model that included all the variables listed in the table. Additive genetic modeling was used for all SNPs. Risk for GRS is per allele, age per year, LA size per mm, LVEF per % increase. All other risks are per risk category.