Table 1.
Characteristics of all Subjects
| Phenotypes | Eosinophilic asthma | Non-eosinophilic asthma | Healthy Control |
|---|---|---|---|
| Number of subjects | 10 | 14 | 12 |
| Sex (female/male) | 4/6 | 9/5 | 5/7 |
| Age/years† | 37.30 (30.25, 46.50) | 37.86 (33.00, 46.75) | 41.00 (31.00, 49.75) |
| BMI/(kg·m-2) † | 23.76 (20.18, 26.08) | 24.99 (21.16, 28.03) | 22.93 (22.04, 25.25) |
| Duration of asthma/years† | 3.75 (2.68,5.00) * | 4.10 (2.85, 5.75) * | 0 |
| Serum IgE/(ng·mL-1) † | 202.1 (125.3, 275.5) ** # | 142.2 (62.02, 209.3) | 124.5 (75.89. 133.3) |
| ACQ6† | 0.9520 (0.6700, 1.170) ** | 1.048 (0.7100, 1.290) ** | N/A |
| ICS/(μg·day-1) † ‡ | 570.0 (425.0, 675.0) ** # | 728.6 (600.0, 800.0) ** | 0 (0, 0) |
| FEV1/FVC (%)† | 65.20 (60.25, 70.50) ** | 65.36 (64.00, 69.75) ** | 79.33 (76.48, 83.02) |
| FEV1/FVC (% post) † | 71.60 (64.50, 77.75) | 72.43 (70.00, 78.50) | N/A |
| FEV1 Reversibility (L) † | 0.3880 (0.3375, 0.4225) | 0.4179 (0.3375, 0.4475) | N/A |
| FEV1 Reversibility (%)† | 24.90 (16.50, 31.50) | 30.07 (18.25, 36.00) | N/A |
| White blood cell counts †§ | 7.127 (5.880, 8.482) | 8.299 (5.865, 9.818) | 7.285 (5.888, 8.175) |
| Eosinophil counts†§ | 0.5630 (0.3500, 0.6975) ** ## | 0.1136 (0.0550, 0.1225) | 0.1120 (0.04750, 0.1700) |
| Eosinophil (%)† | 7.990 (59.25, 9.500) ** ## | 1.293 (0.7750, 2.00) | 1.600 (1.000, 2.000) |
| Lymphocyte (%)† | 28.93 (22.32, 35.28) | 25.33 (20.52. 28.97) * | 33.30 (28.00, 39.50) |
| Neutrophil counts†§ | 4.112 (3.320, 5.025) # | 5.689 (3.285, 7.220) * | 4.277 (3.245, 5.042) |
| Neutrophil (%)† | 56.79 (50.82, 59.60) # | 66.64 (62.00, 71.15) * | 58.00 (53.50, 63.75) |
| Score1† | 19.35 (11.50, 21.12) | 9.850 (8.442, 10.26) | N/A |
| Score2† | 24.03 (12.27, 26.85) | 7.214 (5.535, 9.030) | N/A |
† Data are shown as mean (Q1, Q3). ‡ Dosage of inhaled corticosteroid (ICS) was expressed as beclomethasone propionate equivalent dosage. § Unit for cell count is10^9/L. * P < 0.05 vs Healthy control group, **P < 0.01 vs Healthy control group, # P < 0.05 vs Non-eosinophilic asthma group, ##P < 0.01 vs Non-eosinophilic asthma group. BMI, body mass index; ACQ6, asthma control questionnaire 6; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; Both Score1 and Score2 are calculating results of the clustering formula. If Score1 is less than Socre2, clustering the sample as eosinophilic asthma, otherwise as non-eosinophilic asthma.