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. 2019 Jan 29;16(3):416–423. doi: 10.7150/ijms.26997

Figure 3.

Figure 3

Tumor stromagenesis was repressed in Wnt10a-/- mice. A microscopic examination showed that the pigmented melanomas in Wnt10a-/- mice were significantly associated with more repressed proliferation of α-SMA- or CD31-positive microvessels than in WT mice (n = 8 mice per group), although only in cases where WNT10A and β-catenin co-expression was apparent, especially in tumor vessels. Accordingly, there were significantly fewer microvessels in Wnt10a-/- mice than in WT mice. Scale bars = 100 µm. Values are means ± SE. *P < 0.05, ***P < 0.0001.