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. 2019 Feb 19;15(4):812–825. doi: 10.7150/ijbs.31335

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© Ivyspring International Publisher

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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MMP28 promoted migratory and invasive abilities of HCC cells in vivo and in vitro. (a) The overexpression and knockdown efficiencies of MMP28 in cells were detected by western blot and qPCR. (b) Transwell assays were performed to determine the influence of MMP28 overexpressing on the migratory and invasive abilities in 7402 cells. (c) Transwell assays were performed to determine the influence of MMP28 silencing on the migratory and invasive abilities in Huh7 cells. (d) In vivo effect of MMP28 in lung metastasis model 5 weeks after Huh7-luc cells injected. Representative images of metastasis models were presented on the left, and statistical data was presented on the right. (e) Overall survival of grouped mice. *P < 0.05; **P < 0.01; ***P < 0.001. Data were represented as Means ± SD.