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. 2019 Feb 19;15(4):812–825. doi: 10.7150/ijbs.31335

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Notch3 knockout dispelled the metastasis-promoting ability of MMP28. (a) Levels of NICD3, MMP28, ZEB-1 and ZEB-2 in Notch3-knockout Huh7 stable cells (N3-KO) were determined by western blot. (b) Transwell assays were performed to determine the influence of Notch3 knockout on the migratory and invasive abilities of Huh7 stable cells. (c) The expression of ZEB-1 and ZEB-2 in N3-KO cells transfected with MMP28 was determined by western blot. (d) Transwell assays were performed to determine the influence of MMP28 overexpressing on the migratory and invasive abilities in N3-KO cells. (e) The expression of ZEB-1 and ZEB-2 in N3-KO cells transfected with MMP28 siRNA was determined by western blot. (f) Transwell assays were performed to determine the influence of MMP28 silencing on the migratory and invasive abilities in N3-KO cells. *P < 0.05; **P < 0.01. Data are represented as Means ± SD.