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. 2019 Mar 1;15(4):847–856. doi: 10.7150/ijbs.30970

Figure 4.

Figure 4

PCAT-1 promotes prostate cancer cell proliferation through cMyc. Overexpression of PCAT-1 up-regulates MYC 3'UTR activity, increases cMyc abundance, and promotes prostate cancer cell proliferation. Conversely, PCAT-1 knockdown down-regulates this process and inhibites cancer cell proliferation. Overexpression of miRNA-3667-3p increases the expression level of PCAT-1 and suppresses MYC 3'UTR activity. Overexpression of miR-34a also inhibites MYC 3'UTR activity. Down-regulation of MYC 3'UTR activity reduces cMyc protein abundance and suppresses cancer cell proliferation.