Fig 1.

Effects of farrerol on APAP-induced mortality and liver injury. (A) Mice were administered farrerol (40 mg/kg) i.p. two times at an interval of 12 h. The survival rate of mice who received the last dose of farrerol (40 mg/kg) at 1 h, followed by exposure to a lethal dose of APAP (900 mg/kg) is shown. The data are expressed as the percentage of surviving mice at each point in time, where n=10 in each group. (B) Mice were treated with APAP (900 mg/kg) for 1 h, followed by treatment with farrerol (40 mg/kg) to determine the mortality rate. The data are expressed as the percentage of surviving mice at each point in time point, n=10 in each group. (C, D) At 1 h after the last dose of farrerol, APAP (400 mg/kg) was administered for 3 h (n=10/group). Then, the serum levels of ALT and AST were measured, as shown. (E) Representative images of H & E staining of liver tissues. All of the data shown represent the average from three independent experiments. *p < 0.05 and **p < 0.01 versus the APAP group.