Table 1.
Clinical characteristics and PD-1.6 genotype of 688 HCV-positive patients and 94 HCV-negative BD.
| PD-1.6 A > G (rs10204525) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | Age | Male (%) | MAF∗ | G/G (%) | A/G (%) | A/A (%) | Viral load#° | HCV genotype° (%) | ||
| Control subjects | ||||||||||
| BD | 94 | 42.46 ± 10.1 | 43 (89.6) | 94 | 0.10 | 76 (80.9) | 18 (19.1) | 0 | – | – |
| HCV infected patients with liver diseases | ||||||||||
| CHC | 148 | 57.12 ± 14.1 | 56 (48.3) | 450 | 0.09 | 125 (84.5) | 20 (13.5) | 3 (2.0) | 2.32 ± 3.9 | 51/82 (55.6) |
| Cirrhosis | 113 | 64.46 ± 11.1 | 70 (65.4) | 0.09 | 93 (82.3) | 19 (16.8) | 1 (0.9) | 2.71 ± 4.4 | 15/27 (62.2) | |
| HCC | 189 | 68.86 ± 8.6 | 103 (73.6) | 0.09 | 154 (81.5) | 34 (18.0) | 1 (0.5) | 1.94 ± 1.9 | 3/3 (100) | |
| HCV infected patients with lymphoproliferative diseases | ||||||||||
| MC | 130 | 68.03 ± 9.9 | 32 (29.1) | 238 | 0.11 | 103 (79.2) | 26 (20.0) | 1 (0.8) | 3.32 ± 4.4 | 40/55 (72.7) |
| NHL | 108 | 66.53 ± 15.1 | 47 (47.5) | 0.10 | 87 (80.6) | 20 (18.5) | 1 (0.9) | 3.13 ± 4.2 | 7/11 (63.6) | |
| Total | 782 | 65.9 ± 13.7 | 351 (44.9) | 782 | 0.10 | 638 (81.6) | 137 (17.5) | 7 (0.9) | 2.52 ± 3.9 | 116/178 (65.2) |
BD, blood donors; CHC, chronic hepatitis C; HCC, hepatocellular carcinoma; MC, mixed cryoglobulinemia; NHL, non-Hodgkin lymphoma; ±, standard deviation; ∗MAF, minor allele frequency, corresponding to A allele; #viral load, mean in million; °data of viral load and of HCV genotype type 1 were determined in 178 cases.