FIG 3.

Malaria-exposed adults (n = 10) demonstrated greater serorecognition of and seroreactivity to peptides of three RIFINs (A and C) and six STEVORs (B and D) than children (n = 10) as measured using peptide microarrays. (A and B) Malian adult sera (red) recognized significantly more (A) RIFIN and (B) STEVOR total peptides than preseason pediatric sera (blue). The horizontal axis depicts the relative location of the N-terminal amino acid for each peptide. ***, significant difference between adults and children in serorecognized peptide counts (P < 0.05; McNemar’s test). (C and D) Malian adult sera (red) had increased seroreactivity to subsets of (C) RIFIN and (D) STEVOR peptides compared with pediatric sera (blue) (P values are indicated in gray on the secondary y axis; Wilcoxon rank-sum test).