Table 1.
Proteome: Top 25 proteins with a significantly increased level in tumor necrosis factor (TNF) long term-incubated monocytes. Using liquid chromatography and mass spectrometry (LC-MS/MS) analysis, the proteome in TNF long term-incubated and control monocytes has been analyzed. Subsequently, the ratio between the proteins in TNF long term-incubated and control cells was calculated (protein TNF/protein control). Cellular processes influenced by the respective genes are also provided.
| Protein Name | Protein Ratio | Function |
|---|---|---|
| IDO1 | 19.4 | metabolism |
| SIGLEC10 | 16.3 | cell structure/signalling |
| MYH11 | 16 | cell structure |
| NFKB2 | 15.8 | gene regulation |
| SRSF2 | 10.8 | gene regulation |
| LAD1 | 10.6 | cell structure |
| CD82 | 9.3 | cell structure/signalling |
| CLIC4 | 8.4 | cell structure |
| KYNU | 8.1 | metabolism |
| AIM1 | 7.9 | cell structure |
| FSCN1 | 7.6 | cell structure |
| RELB | 7 | gene regulation |
| PPA1 | 7 | metabolism |
| CYP27A1 | 6.5 | metabolism |
| SET | 6.1 | gene regulation |
| SMAP | 6.1 | cell structure |
| PILRA | 5.4 | signalling |
| MPHOSPH8 | 5.4 | gene regulation |
| NQO1 | 5.2 | metabolism |
| IL18 | 5.2 | signalling |
| TRIP10 | 5.1 | cell structure |
| GRAMD1A | 5.1 | unknown |
| ADI1 | 5.0 | metabolism |
| AK4 | 4.8 | metabolism |
| CAST | 4.6 | proteolysis |