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Growth inhibition by compounds 3–6 against a panel of human tumor cell lines a.
| Compound | Cell Line (GI50 μM) b | |||||
|---|---|---|---|---|---|---|
| HCT-15 | NCI-H23 | ACHN | MDA-MB-231 | NUGC-3 | PC-3 | |
| 3 | 8.2 | 7.1 | 8.0 | 7.3 | 6.5 | 8.1 |
| 4 | 25.0 | 26.2 | 26.2 | 23.2 | 14.9 | 24.7 |
| 5 | 8.1 | 7.8 | 7.4 | 7.3 | 7.9 | 8.8 |
| 6 | >60 | >60 | >60 | >60 | >60 | >60 |
| Doxorubicin | 0.2 | 0.1 | 0.1 | 0.1 | 0.1 | 0.2 |
a HCT-15, colon cancer; NCI-H23, lung cancer; ACHN, renal cancer; MDA-MB-231, breast cancer; NUGC-3, stomach cancer; PC-3, prostate cancer. b Data are an average of at least two tests.
