Table 2.

Antifungal activity of dihydrofuranaphthoquinones over time and at different storage temperatures against S. brasiliensis and S. schenckii fungi.

DihydrofuraNa-Phthoquinone	Time and Condition	MIC (µM)
	Time (day)	S. brasiliensis	S. schenckii
5	0	16	32
	60, refrigerator	8	16
	60, room temperature	16	16
	90, refrigerator	16	16
	90, room temperature	8	4
6	0	4	4
	60, refrigerator	4	4
	60, room temperature	4	4
	90, refrigerator	4	4
	90, room temperature	4	4
7	0	32	32
	60, refrigerator	8	16
	60, room temperature	8	16
	90, refrigerator	16	16
	90, room temperature	16	16
8	0	4	8
	60, refrigerator	8	8
	60, room temperature	16	32
	90, refrigerator	16	16
	90, room temperature	16	16
10	0	2	4
	60, refrigerator	4	4
	60, room temperature	4	4
	90, refrigerator	4	4
	90, room temperature	16	8
17	0	16	32
	60, refrigerator	16	16
	60, room temperature	16	16
	90, refrigerator	>32	>32
	90, room temperature	>32	>32
18	0	4	8
	60, refrigerator	4	8
	60, room temperature	4	8
	90, refrigerator	8	8
	90, room temperature	8	8
20	0	16	16
	60, refrigerator	16	16
	60, room temperature	16	16
	90, refrigerator	>32	32
	90, room temperature	>32	32
21	0	32	16
	60, refrigerator	4	8
	60, room temperature	4	8
	90, refrigerator	4	8
	90, room temperature	4	8
Itraconazole		0.25	0.125

MIC: minimum inhibitory concentration. The results represent two independent experiments in duplicate. T0 = 0 days; T60 = 60 days; T90 = 90 days.