Table 3.

Associations of itraconazole and Compounds 6 and 10 against S. schenckii and S. brasiliensis yeast cells. MIC values are in µM.

	MIC Drugs Tested Alone		MIC b Drugs in Combination	ΣFIC Index a
	Itraconazole	6	Itraconazole/6
S. brasiliensis	0.25	4	0.25/0.5	1.13
S. schenckii	0.125	4	0.06/0.25	0.54
	Itraconazole	10	Itraconazole/10
S. brasiliensis	0.25	2	0.25/0.25	1.13
S. schenckii	0.125	4	0.03/0.25	0.30

^a Fractional inhibitory concentration index; ΣFIC index = (MICa in combination/MICa tested alone) + (MICb in combination/MICb tested alone), where a and b are itraconazole and naphthoquinone (10 or 6), respectively. ^b Combinations with the lowest ΣFIC index. MIC was the lowest concentration able to inhibit 50% of fungal growth (mean of two independent experiments).