Table 2.
Cancer-induced changes in gene expression of nuclear ERK substrates that are localized in the nucleus and other organelles. Listed are direct ERK substrates localized in the nucleus as well as in at least one additional organelle. The data bases and calculations are similar to ones presented in Table 1. The additional localization of each of the substrates as appear in UniProt and the Human Protein Atlas is indicated as well. * The protein PRRC2A that appears in the nucleus, cytosol, and plasma membrane does not exist in TCGA Pan-Cancer Dataset, therefore we did not refer to its expression in tumor and normal tissues.
| Gene | Gene Expression | p-Value | Fold Change | Other Localizations | |
|---|---|---|---|---|---|
| Tumor | Normal | ||||
| NR4A1 | 10.47 | 12.37 | 3.4 × 10−118 | −3.73 | cytosol |
| CBX7 | 9.50 | 10.94 | 1.9 × 10−223 | −2.72 | cytosol |
| CRYAA | 0.99 | 2.24 | 4.1 × 10−17 | −2.38 | cytosol |
| ERG | 7.80 | 8.98 | 1.4 × 10−106 | −2.27 | cytosol |
| RBPMS | 9.75 | 10.88 | 1.3 × 10−124 | −2.19 | cytosol |
| FOXO1 | 9.25 | 10.36 | 2.7 × 10−189 | −2.17 | cytosol |
| CRY2 | 9.75 | 10.82 | 8.4 × 10−219 | −2.09 | cytosol |
| NR3C1 | 9.93 | 10.89 | 3.1 × 10−161 | −1.95 | cytosol + mitochondria |
| AIM1 | 9.64 | 10.57 | 2.4 × 10−52 | −1.91 | cytosol + microtubules |
| EGFR | 9.23 | 10.06 | 2.5 × 10−76 | −1.78 | plasma membrane |
| ETS2 | 11.23 | 12.01 | 1.6 × 10−69 | −1.72 | cytosol + plasma membrane |
| NCOA1 | 10.21 | 10.74 | 3.5 × 10−112 | −1.44 | cytosol + plasma membrane |
| FGFR1 | 10.27 | 10.77 | 2.3 × 10−24 | −1.42 | plasma membrane |
| RPS6KA3 | 10.33 | 10.82 | 1.2 × 10−85 | −1.40 | cytosol |
| SMAD4 | 10.43 | 10.92 | 2.5 × 10−158 | −1.40 | cytosol |
| STAT5A | 9.48 | 9.94 | 5.8 × 10−36 | −1.38 | cytosol |
| SORBS3 | 10.76 | 11.22 | 4.4 × 10−72 | −1.37 | focal adhesion sites |
| FOXO3 | 10.44 | 10.82 | 1.6 × 10−48 | −1.30 | cytosol |
| BCL6 | 9.96 | 10.29 | 1.4 × 10−14 | −1.25 | Golgi |
| CRY1 | 8.74 | 9.03 | 1.9 × 10−33 | −1.22 | microtubules |
| SREBF2 | 11.72 | 11.98 | 2.6 × 10−24 | −1.20 | mitochondria |
| WASL | 10.75 | 11.00 | 4.9 × 10−43 | −1.19 | cytosol |
| SMAD3 | 10.45 | 10.70 | 7.8 × 10−25 | −1.19 | cytosol |
| SMAD2 | 10.63 | 10.79 | 3.6 × 10−19 | −1.12 | cytosol |
| SMAD1 | 9.25 | 9.40 | 9.9 × 10−12 | −1.11 | cytosol + plasma membrane |
| RPS6KA1 | 10.22 | 10.25 | 0.59 | −1.02 | cytosol |
| PIP5K1C | 10.36 | 10.32 | 0.16 | 1.03 | cytosol |
| MKL1 | 9.98 | 9.90 | 1.2 × 10−4 | 1.06 | cytosol |
| RAI14 | 10.11 | 10.02 | 1.4 × 10−2 | 1.06 | cytosol |
| NFATC4 | 8.76 | 8.59 | 1.4 × 10−3 | 1.12 | cytosol |
| TGS1 | 9.07 | 8.91 | 3.1 × 10−18 | 1.12 | cytosol |
| HNRNPH1 | 12.00 | 11.83 | 2.4 × 10−21 | 1.13 | cytosol |
| ETV6 | 9.99 | 9.81 | 5.6 × 10−9 | 1.14 | cytosol |
| STAT1 | 12.23 | 11.80 | 3.1 × 10−43 | 1.35 | cytosol |
| PPP1R9B | 10.73 | 10.29 | 5.6 × 10−72 | 1.36 | cytoskeleton |
| DAZAP1 | 10.82 | 10.34 | 2.7 × 10−113 | 1.39 | cytosol |
| POU5F1 | 3.91 | 3.42 | 1.5 × 10−12 | 1.40 | cytosol |
| HSF1 | 10.98 | 10.48 | 3.3 × 10−148 | 1.41 | cytosol |
| MYB | 6.43 | 5.58 | 2.4 × 10−11 | 1.80 | plasma membrane |
| SMC4 | 10.42 | 9.42 | 5.6 × 10−157 | 2.00 | cytosol |
| MAGEA11 | 1.33 | 0.27 | 1.0 × 10−159 | 2.08 | cytosol |
| PTTG1 | 8.68 | 6.19 | 1.2 × 10−140 | 5.63 | cytosol |
| TPX2 | 9.75 | 6.59 | 5.7 × 10−216 | 8.95 | microtubules |
| *PRRC2A | NA | NA | NA | NA | cytosol + plasma membrane |