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. 2019 Mar 5;20(5):1115. doi: 10.3390/ijms20051115
ABC advanced breast cancer
ADC antibody-drug-conjugates
AE adverse event
AF-HPA auristatin f-hydroxypropylamide
ALT alanine transaminase
AST aspartate transaminase
CBR clinical benefit rate
CI confidence interval
CR complete response
DAR drug antibody ratio
DCR disease control rate
DFS disease-free survival
DOR duration of response
EGF epidermal growth factor
EGFR epidermal growth factor receptor
HER2 human epidermal growth factor receptor 2
HER3 human epidermal growth factor receptor 3
HER4 human epidermal growth factor receptor 4
ISH in situ hybridization
IHC immunohistochemistry
ILD interstitial lung disease
MBC metastatic breast cancer
MDT maximum tolerated dose
MMAE monomethyl auristatin E
MMAF monomethyl auristatin F
ORR overall response rate
PFS progression-free survival
PBD-MA pyrrolo[2,1-c][1,4]benzodiazepine monoamide
PR partial response
Q2W every 2 weeks
Q3W every 3 weeks
ROR2 receptor tyrosine kinase-like orphan receptor 2
RP2D recommended phase 2 dose
SAE serious adverse event
SD stable disease