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. 2019 Mar 15;10:186. doi: 10.3389/fgene.2019.00186

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Copyright © 2019 Choupani, Nariman-Saleh-Fam, Saadatian, Ouladsahebmadarek, Masotti and Bastami.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of hsa-mir-149 locus and effect of rs2292832 on its processing. (A) Top: Hsa-mir-149 generates two mature miRNAs (miR-149-5p and miR-149-3p), and rs2292832 resides in pre-miRNA sequence, but not in either mature miRNAs, at GRCh37 chr2: 241,395,593. Bottom: Stem-loop structure of hsa-mir-149, including mature miR-149-5p (Red), and miR-149-3p (Blue) sequences. (B) Rs12292832 may alter miRNA processing and decrease mature miR-149 (−5p and −3p forms) expression.