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. 2019 Mar 15;10:186. doi: 10.3389/fgene.2019.00186

Table 1.

Main characteristics of studies evaluating cancer risk associated with miR-196a-2 rs11614913 C/T which included in the current meta-analysis.

N References Country Ethnicity Genotyping Method Design Cases/
Controls 		Genotype distributiona Cancer Type Quality Score PHWE
Cases Controls
1 Abdel-Hamid et al., 2018 Egypt African PCR-RFLP PB 50/50 21/26/3 24/20/6 HCC 10 0.53
2 Damodaran et al., 2018 India Asian PCR-RFLP HB 100/100 32/51/17 47/36/17 PC 7 0.054
3 Doulah et al., 2018 Iran Asian ARMS-PCR HB 98/100 33/51/14 25/62/13 BC 3 0.015
4 He J. et al., 2018 China Asian TaqMan HB 393/812 94/192/107 183/399/230 NB 11 0.73
5 Mashayekhi et al., 2018 Iran Asian PCR-RFLP HB 353/353 142/169/42 149/158/46 BC 10 0.75
6 Minh et al., 2018 Vietnam Vietnamese HRMA HB 113/127 48/35/30 31/64/32 BC 5 0.95
7 Afsharzadeh et al., 2017 Iran Asian ARMS-PCR Not mentioned 100/150 34/52/14 38/93/19 BC 3 0.002
8 Bodal et al., 2017 India Asian PCR-RFLP HB 95/99 48/47/0 64/35/0 BC 8 0.051
9 Huang et al., 2017 China Asian PCR-RFLP PB 165/284 22/81/62 39/134/111 HCC 9 0.95
10 Poltronieri-Oliveira et al., 2017 Brazil Mixed PCR-RFLP PB 149/246 64/57/28 105/120/21 GC 9 0.12
11 Rakmanee et al., 2017 Thiland Asian PCR-RFLP HB 104/180 48/43/13 49/78/53 ALL 9 0.09
12 Rogoveanu et al., 2017 Romania Caucasian TaqMan HB 142/288 61/63/18 121/128/39 GC 9 0.64
13 Srivastava et al., 2017 India Asian PCR-RFLP HB 184/164 20/93/71 21/81/62 CSCC 1- 0.57
14 Yin et al., 2017 China Asian TaqMan HB 1,003/1,003 252/555/196 221/496/286 LC 1- 0.86
15 Zhang E. et al., 2017 China Asian TaqMan HB 340/340 71/169/100 88/155/97 OC 11 0.12
16 Dai et al., 2016 China Asian Mass-ARRAY HB 560/583 197/265/98 155/284/144 BC 10 0.58
17 Gu and Tu, 2016 China Asian PCR-RFLP HB 186/186 39/96/51 57/98/31 GC 7 0.36
18 Hashemi et al., 2016 Iran Asian t-ARMS-PCR HB 169/182 64/88/17 77/93/12 PC 7 0.029
19 Li M. et al., 2016 China Asian MassARRAY HB 182/182 24/83/75 11/79/92 GC 8 0.33
20 Li J. et al., 2016 China Asian Sequencing Not mentioned 109/105 25/64/20 18/52/35 HCC 8 0.95
21 Miao et al., 2016 China Asian Array (Illumina Infinium1) HB 576/1,550 130/284/162 292/755/503 HNSCC 12 0.80
22 Morales et al., 2016 Chile Mixed TaqMan PB 440/807 192/191/57 342/351/114 BC 12 0.13
23 Ni and Huang, 2016 China Asian PCR-RFLP HB 155/342 32/82/41 66/176/100 OvC 9 0.51
24 Peckham-Gregory et al., 2016 USA Caucasian Allele-specific PCR Array PB 179/529 72/88/19 196/257/76 NHL 13 0.62
25 Shen et al., 2016 China Asian SNaPshot PB 1,400/2,185 295/698/407 392/1121/672 ESCC 10 0.046
26 Song et al., 2016 China Asian PCR-RFLP PB 479/431 121/247/111 86/203/142 OvC 13 0.42
27 Su et al., 2016 China Asian PCR-RFLP HB 245/315 83/128/34 119/158/38 GC 10 0.22
28 Sun et al., 2016 China Asian PCR-RFLP HB 134/227 29/66/39 34/116/77 OvC 7 0.42
29 Toraih et al., 2016b Egypt African TaqMan HB 209/100 84/93/32 55/35/10 Cancer 8 0.30
30 Toraih et al., 2016a Egypt African TaqMan PB 125/150 48/63/14 80/53/17 Cancer 11 0.11
31 Wang et al., 2017 China Asian Mass-ARRAY PB 283/283 73/158/52 65/124/94 BlC 10 0.066
32 Yin et al., 2016 China Asian TaqMan HB 575/608 128/298/149 133/297/178 LC 14 0.70
33 Zhang L. H. et al., 2016 China Asian PCR-RFLP PB 175/302 25/85/65 42/138/122 HCC 9 0.83
34 Zhao et al., 2016 China Asian Sequencing HB 114/114 31/50/33 28/61/25 BC 9 0.53
35 Zhou et al., 2011 China Asian PCR-RFLP HB 226/309 46/123/57 58/169/82 CSCC 12 0.09
36 Deng et al., 2015 China Asian PCR-RFLP PB 159/298 41/66/52 56/166/76 BlC 9 0.048
37 Dikaiakos et al., 2015 Greece Caucasian PCR-RFLP PB 157/299 19/69/69 33/149/117 CRC 10 0.18
38 He et al., 2015 China Asian Mass-ARRAY PB 450/450 81/233/136 93/223/134 BC 11 0.94
39 Li T. et al., 2015 China Asian PCR-RFLP PB 318/320 61/146/111 42/134/144 NHL 13 0.26
40 Liu, 2015 China Asian PCR-RFLP PB 266/266 84/131/51 113/123/30 HCC 12 0.76
41 Liu, 2015 China Asian PCR-RFLP HB 216/100 25/133/58 23/49/28 GyC 5 0.95
42 Martin-Guerrero et al., 2015 Spain Caucasian TaqMan PB 104/345 35/40/29 137/159/49 CLL 9 0.86
43 Nikolić et al., 2015 Serbia Caucasian HRMA PB 351/309 150/161/40 121/147/41 PC 10 0.79
44 Qi et al., 2015 China Asian TaqMan PB 321/290 34/119/168 17/88/185 BC 11 0.18
45 Sodhi et al., 2015 India Asian PCR-RFLP PB 250/255 70/161/19 101/146/8 LC 12 5.46e−7
46 Sushma et al., 2015 India Asian PCR-RFLP PB 100/102 22/10/68 6/15/81 OC 8 0.001
47 Yan et al., 2015 China Asian PCR-RFLP HB 274/328 46/147/81 27/165/136 HCC 9 0.02
48 Yin et al., 2015 China Asian TaqMan HB 258/310 50/141/67 63/150/97 LC 11 0.78
49 Bansal et al., 2014 India Asian PCR-RFLP PB 121/165 68/41/12 85/59/21 BC 9 0.058
50 Chu et al., 2014 Taiwan Asian PCR-RFLP PB 188/337 41/81/66 70/167/100 HCC 12 0.94
51 Dikeakos et al., 2014 Greece Caucasian PCR-RFLP HB 163/480 102/46/15 79/229/172 GC 9 0.9
52 Hao et al., 2014 China Asian PCR-RFLP PB 235/282 77/126/32 67/160/55 HCC 11 0.027
53 Kou et al., 2014 China Asian PCR-RFLP PB 271/532 84/150/37 125/304/103 HCC 9 0.001
54 Kupcinskas et al., 2014b Latvia Caucasian TaqMan HB 363/350 144/184/35 159/145/46 GC 8 0.18
55 Kupcinskas et al., 2014a Latvia Caucasian TaqMan HB 193/427 79/87/27 199/174/54 CRC 8 0.12
56 Li et al., 2014 China Asian TaqMan PB 1,020/1,006 209/489/322 218/518/270 NC 13 0.32
57 Du et al., 2014 China Asian TaqMan PB 1,000/1,022 149/514/337 211/497/314 RCC 13 0.61
58 Omrani et al., 2014 Iran Asian T-ARMS-PCR PB 236/203 218/18/0 178/25/0 BC 11 0.70
59 Parlayan et al., 2014 Japan Asian TaqMan HB 827/524 174/409/244 108/270/146 Cancer 11 0.44
60 Pu et al., 2014 China Asian PCR-RFLP HB 159/511 39/95/25 101/324/86 GC 9 1.7e−9
61 Qi et al., 2014 China Asian HRMA PB 314/406 45/209/60 71/214/121 HCC 12 0.17
62 Qu et al., 2014 China Asian PCR-RFLP PB 381/426 126/207/48 133/211/82 ESCC 13 0.96
63 Roy et al., 2014 India Asian TaqMan HB 451/448 218/187/46 242/168/38 OC 10 0.29
64 Tong et al., 2014 China Asian TaqMan PB 570/673 103/308/159 129/307/237 ALL 14 0.11
65 Wang N. et al., 2014 China Asian PCR-LDR PB 597/597 128/307/162 145/298/154 ESCC 13 0.97
66 Zhou et al., 2014 China Asian PCR-RFLP HB 266/281 93/139/34 66/160/55 HCC 10 0.02
67 Ahn et al., 2013 South Korea Asian PCR-RFLP PB 461/447 100/242/119 87/232/128 GC 12 0.35
68 Han et al., 2013 China Asian TaqMan PB 1,017/1,009 207/505/305 220/485/304 HCC 10 0.33
69 Hu et al., 2013 China Asian Sequencing HB 680/690 185/314/181 138/342/210 Glioma 14 0.98
70 Liu et al., 2013 Taiwan Asian PCR-RFLP NA 315/92 64/147/104 26/36/30 OC 6 0.055
71 Lv et al., 2013 China Asian PCR-RFLP PB 347/531 10/223/114 109/331/91 CRC 10 1.5e−8
72 Ma et al., 2013 China Asian Mass-ARRAY PB 190/187 44/92/54 49/79/59 BC 11 0.047
73 Min et al., 2012 South Korea Asian PCR-RFLP PB 446/502 120/201/125 100/254/148 CRC 12 0.68
74 Pavlakis et al., 2013 Greece Caucasian PCR-RFLP PB 93/122 12/33/48 14/58/50 PNC 10 0.75
75 Umar et al., 2013 India Asian PCR-RFLP PB 289/309 146/121/22 171/122/16 ESCC 12 0.39
76 Vinci et al., 2013 Italy Caucasian HRMA HB 160/178 62/86/12 83/84/11 CRC 9 0.11
77 Wang et al., 2013 China Asian TaqMan HB 1,689/1,946 319/851/519 482/940/524 GC 10 0.14
78 Wei et al., 2013 China Asian Mass-ARRAY HB 367/370 65/196/106 87/170/113 ESCC 12 0.16
79 Zhang et al., 2013 China Asian Mass-ARRAY PB 996/995 214/488/294 165/502/328 HCC 10 0.26
80 Alshatwi et al., 2012 Saudi Arabia Asian TaqMan HB 100/100 35/63/2 46/50/4 BC 4 0.051
81 Chen et al., 2012 China Asian PCR-LDR HB 126/407 27/64/35 94/206/107 CRC 12 0.84
82 Chu et al., 2012 Taiwan Asian PCR-RFLP PB 470/425 57/277/136 87/206/132 OC 11 0.68
83 Hezova et al., 2012 Czech Republic Caucasian TaqMan PB 197/212 82/89/26 87/103/22 CRC 9 0.34
84 Kim et al., 2012 South Korea Asian PCR-RFLP PB 159/201 34/84/41 45/107/49 HCC 11 0.41
85 Linhares et al., 2012 Brazil Mixed TaqMan HB 388/388 94/177/117 127/165/96 BC 7 0.005
86 Zhang M. et al., 2012 China Asian PCR-RFLP PB 248/243 11/89/148 17/93/133 BC 13 0.96
87 Zhu et al., 2012 China Asian TaqMan HB 573/588 140/303/130 121/295/172 CRC 12 0.83
88 Akkiz et al., 2011 Turkey Asian PCR-RFLP HB 185/185 77/86/22 58/87/40 HCC 12 0.56
89 George et al., 2011 India Asian PCR-RFLP PB 159/230 55/101/3 106/114/10 PC 10 0.003
90 Hong et al., 2011 South Korea Asian TaqMan HB 406/428 86/224/96 96/198/134 LC 12 0.18
91 Jedlinski et al., 2011 Australia Caucasian PCR-RFLP PB 187/171 68/86/33 58/82/31 BC 9 0.91
92 Mittal et al., 2011 India Asian PCR-RFLP HB 212/250 76/131/5 109/127/14 BlC 10 0.004
93 Vinci et al., 2011 Italy Caucasian HRMA HB 101/129 35/54/12 58/61/10 LC 9 0.34
94 Zhan et al., 2011 China Asian PCR-RFLP HB 252/543 68/128/56 113/267/163 CRC 11 0.89
95 Catucci et al., 2010 Italy Caucasian TaqMan PB 751/1243 334/330/87 532/550/161 BC 11 0.33
Germany Caucasian TaqMan PB 1,101/1,496 432/512/157 584/696/216 BC 11 0.74
96 Christensen et al., 2010 USA Caucasian TaqMan PB 484/555 182/224/78 188/279/88 HNSCC 14 0.39
97 Dou et al., 2010 China Asian PCR-LDR HB 643/656 111/343/189 143/305/208 Glioma 11 0.13
98 Li et al., 2010 China Asian PCR-RFLP HB 310/222 78/150/82 42/102/78 HCC 9 0.46
99 Liu et al., 2010 USA Caucasian PCR-RFLP HB 1,109/1,130 350/565/194 383/545/202 HNSCC 13 0.77
100 Okubo et al., 2010 Japan Asian PCR-RFLP HB 552/697 105/281/166 124/350/223 GC 11 0.54
101 Peng et al., 2010 China Asian PCR-RFLP HB 213/213 76/94/43 56/107/50 GC 10 0.96
102 Qi et al., 2010 China Asian PCR-LDR PB 361/391 82/179/100 92/197/102 HCC 10 0.92
103 Srivastava et al., 2010 India Asian PCR-RFLP PB 230/230 119/95/16 136/75/19 GBC 12 0.09
104 Wang et al., 2010 China Asian SNaPshot HB 458/489 148/262/48 128/250/111 ESCC 11 0.64
105 Kim et al., 2010 Korea Asian PCR-RFLP PB 654/640 187/305,162 155/300/185 LC 14 0.14
106 Hoffman et al., 2009 USA Caucasian Mass-ARRAY HB 426/466 181/209/36 166/229/71 BC 9 0.63
107 Hu et al., 2009 China Asian PCR-RFLP PB 1,009/1,093 239/483/287 218/517/358 BC 14 0.22
108 Tian et al., 2009 China Asian PCR-RFLP PB 1,058/1,035 253/512/293 209/519/307 LC 14 0.73
109 Horikawa et al., 2008 USA Caucasian Capillary electrophoresis PB 276/277 105/126/45 101/117/59 RCC 11 0.03
110 Yang et al., 2008 USA Caucasian Capillary electrophoresis PB 736/731 255/348/133 257/342/132 BlC 13 0.35

Genotype distributions are sorted as CC/CT/TT.

a

Genotype distributions are sorted as CC/CT/TT. PB, population-based design; HB, hospital-based design; NC, Not clear; ALL, Acute myeloblastic leukemia; BC, Breast cancer; BlC, Bladder cancer; CLL, Chronic lymphoblastic leukemia; CRC, Colorectal cancer; CSCC, Cervical Squamous Cell Carcinoma; ESCC, Esophageal squamous cell carcinoma; GBC, Gallbladder carcinoma; GC, Gastric cancer; HCC, Hepatocellular carcinoma; HNSCC, Head and neck squamous cell carcinoma; LC, Lung cancer; NB, Neuroblastoma; NC, Nasopharyngeal carcinoma; NHL, non-Hodgkin lymphoma; OC, Oral cancer; OvC, Ovarian cancer; PC, Prostate cancer; PNC, Pancreatic cancer; RCC, Renal cell carcinoma.