Table 3.
Genetic models | na | Cases/controls | ORb (95% CI) | Pc | PHetd | I2 | Pblase |
---|---|---|---|---|---|---|---|
miR-196a2 rs11614913 | |||||||
Homozygote (TT vs. CC) | 109 | 41,342/49,268 | 0.88 (0.79–0.98) | 0.027 | <0.0001 | 77.1% | 0.370 |
Heterozygote (CT vs. CC) | 111 | 41,673/49,570 | 1.00 (0.92–1.07) | 0.960 | <0.0001 | 70.4% | 0.832 |
Dominant (TT+CT vs. CC) | 111 | 41,673/49,570 | 0.96 (0.89–1.04) | 0.429 | <0.0001 | 76.8% | 0.666 |
Recessive (TT vs. CT+CC) | 109 | 41,342/49,268 | 0.89 (0.83–0.95) | 0.001 | <0.0001 | 68.6% | 0.496 |
Allelic (T vs. C) | 111 | 41,673/49,570 | 0.95 (0.90–1.00) | 0.051 | <0.0001 | 78.9% | 0.148 |
miR-149 rs2292832 | |||||||
Homozygotef (TT vs. CC) | 44 | 15,954/19,594 | 0.89 (0.77–1.02) | 0.119 | <0.0001 | 64.2 | 0.004 |
Heterozygote (CT vs. CC) | 44 | 15,954/19,594 | 0.96 (0.87–1.05) | 0.427 | 0.008 | 37.1 | 0.478 |
Dominant (CT+TT vs. CC) | 44 | 15,954/19,594 | 1.00 (0.90–1.11) | 0.955 | <0.0001 | 53.5 | 0.175 |
Recessivef (TT vs. CC+CT) | 44 | 15,954/19,594 | 1.00 (0.92–1.08) | 0.907 | <0.0001 | 48.6 | 0.045 |
Allelic (T vs. C)f | 44 | 15,954/19,594 | 0.96 (0.88–1.04) | 0.358 | <0.0001 | 73.6 | 0.026 |
Number of studies in each contrast.
Pooled OR and 95% CI (Random-effect model).
P-value of the Z-test.
P-value of the Q-test.
P-value of the Begg's test.
For these models (homozygote, recessive, and allelic comparisons of rs2292832) “trim and fill” adjusted results are shown (consult with Supplementary Figure S4 for forest plots and Supplementary Figure S11 for funnel plots of these models).
Significant associations are shown in boldface.