. 2019 Mar 15;10:186. doi: 10.3389/fgene.2019.00186

Table 3.

Summary of the results of meta-analysis of cancer risk associated with miR-196a-2 rs11614913 and miR-149 rs2292832.

Genetic models	n^a	Cases/controls	OR^b (95% CI)	P^c	P_Het^d	I²	P_blas^e
miR-196a2 rs11614913
Homozygote (TT vs. CC)	109	41,342/49,268	0.88 (0.79–0.98)	0.027	<0.0001	77.1%	0.370
Heterozygote (CT vs. CC)	111	41,673/49,570	1.00 (0.92–1.07)	0.960	<0.0001	70.4%	0.832
Dominant (TT+CT vs. CC)	111	41,673/49,570	0.96 (0.89–1.04)	0.429	<0.0001	76.8%	0.666
Recessive (TT vs. CT+CC)	109	41,342/49,268	0.89 (0.83–0.95)	0.001	<0.0001	68.6%	0.496
Allelic (T vs. C)	111	41,673/49,570	0.95 (0.90–1.00)	0.051	<0.0001	78.9%	0.148
miR-149 rs2292832
Homozygote^f (TT vs. CC)	44	15,954/19,594	0.89 (0.77–1.02)	0.119	<0.0001	64.2	0.004
Heterozygote (CT vs. CC)	44	15,954/19,594	0.96 (0.87–1.05)	0.427	0.008	37.1	0.478
Dominant (CT+TT vs. CC)	44	15,954/19,594	1.00 (0.90–1.11)	0.955	<0.0001	53.5	0.175
Recessive^f (TT vs. CC+CT)	44	15,954/19,594	1.00 (0.92–1.08)	0.907	<0.0001	48.6	0.045
Allelic (T vs. C)^f	44	15,954/19,594	0.96 (0.88–1.04)	0.358	<0.0001	73.6	0.026

Number of studies in each contrast.

Pooled OR and 95% CI (Random-effect model).

P-value of the Z-test.

P-value of the Q-test.

P-value of the Begg's test.

For these models (homozygote, recessive, and allelic comparisons of rs2292832) “trim and fill” adjusted results are shown (consult with Supplementary Figure S4 for forest plots and Supplementary Figure S11 for funnel plots of these models).

Significant associations are shown in boldface.