Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 7;24(5):946. doi: 10.3390/molecules24050946

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Scheme 1 — Reagents and conditions: (a) 4-Cyanophenylboronic acid, Pd(PPh₃)₄, Na₂CO₃/H₂O, dioxane, reflux. (b) 3-Amino-4-allkyl or aryl aminobenzonitrile, sodium metabisulfite, DMF, reflux. (c) i. LiN(TMS)₂/THF, rt ii. HCl/ethanol. (d) RNH₂/EtOH or Cs₂CO₃/DMA. (e) 4-cyanophenylboronic acid, Pd(PPh₃)₄, Na₂CO₃/H₂O, dioxane, reflux. (f) SnCl₂/EtOH, reflux. (g) Na₂S₂O₅/DMSO, 130 °C (h) i. LiN(TMS)₂/THF, ii-HCI/EtOH.