Table 2.
The list of 35 cellular/physiological pathways targeted by the enrichment analysis (KEGG Pathways) with DAVID 6.7. The analysis includes results from a list of 429 genes. N = number of genes participating to the KEGG Pathway. % = percentage of genes in the total of 429 genes. Category = represents the general cellular/physiological function to which the KEGG pathway is involved in. The Kegg pathway terms in red are not supported by significant P-values (P > 0.05). Categories: a = Metabolism. b = Cellular differentiation/survival. c = Cellular organization/adhesion. d = Cancer. e = Development. f = Immune response. g = Reproduction. h = Inflammatory processes. I = Neuronal transmission.
| KEGG Pathway Terms | N | % | p-Value | Category |
|---|---|---|---|---|
| Nitrogen metabolism | 11 | 2.5 | 3.40 × 10−12 | a |
| PPAR signaling pathway | 11 | 2.5 | 1.30 × 10−5 | a |
| Mineral absorption | 9 | 2.1 | 2.70 × 10−5 | a |
| Neurotrophin signaling pathway | 14 | 3.2 | 2.40 × 10−5 | b |
| Regulation of actin cytoskeleton | 18 | 4.2 | 6.30 × 10−5 | c |
| ErbB signaling pathway | 11 | 2.5 | 1.30 × 10−4 | b, d |
| Adherens junction | 8 | 1.9 | 3.30 × 10−3 | c |
| Ras signaling pathway | 15 | 3.5 | 3.80 × 10−3 | b, c |
| MAPK signaling pathway | 16 | 3.7 | 4.20 × 10−3 | b, h |
| Fc gamma R-mediated phagocytosis | 8 | 1.9 | 8.30 × 10−3 | b, c, f |
| Proteoglycans in cancer | 13 | 3 | 9.20 × 10−3 | b, c, d |
| Tight junction | 8 | 1.9 | 1.00 × 10−2 | b, c |
| Epithelial cell signaling in Helicobacter pylori infection | 7 | 1.6 | 1.00 × 10−2 | b, f, h |
| Pathogenic Escherichia coli infection | 6 | 1.4 | 1.30 × 10−2 | c, f, h |
| Rap1 signaling pathway | 13 | 3 | 1.30 × 10−2 | b, c |
| Leukocyte transendothelial migration | 9 | 2.1 | 1.40 × 10−2 | c, f, h |
| Endocytosis | 14 | 3.2 | 1.60 × 10−2 | a, c |
| cAMP signaling pathway | 12 | 2.8 | 2.10 × 10−2 | b, c, e, f, g |
| Salmonella infection | 7 | 1.5 | 4.60 × 10−2 | b, f, h |
| Renal cell carcinoma | 6 | 1.4 | 3.50 × 10−2 | b, d |
| Arhythmogenic right ventricular cardiomyopathy (ARVC) | 6 | 1.4 | 4.20 × 10−2 | c, f, h |
| Cell adhesion molecules (CAMs) | 9 | 2.1 | 4.20 × 10−2 | c, f |
| Inflammatory mediator regulation of TRP channels | 7 | 1.6 | 4.30 × 10−2 | h |
| Estrogen signaling pathway | 7 | 1.6 | 4.60 × 10−3 | b, g |
| T cell receptor signaling pathway | 7 | 1.6 | 5.80 × 10−2 | b, f, h |
| Choline metabolism in cancer | 7 | 1.6 | 6.00 × 10−2 | b, c, h |
| Dopaminergic synapse | 8 | 1.9 | 6.40 × 10−2 | i |
| Bacterial invasion of epithelial cells | 6 | 1.4 | 6.40 × 10−2 | c, f, h |
| Non-small cell lung cancer | 5 | 1.8 | 6.80 × 10−2 | b, d |
| Regulation of lipolysis in adipocytes | 5 | 1.8 | 5.80 × 10−2 | a |
| Hepatitis C | 8 | 1.9 | 7.50 × 10−2 | d, h |
| Apoptosis | 5 | 1.2 | 9.10 × 10−2 | b, d |
| Shigellosis | 5 | 1.2 | 1.00 × 10−1 | d, h |
| Central carbon metabolism in cancer | 5 | 1.2 | 1.00 × 10−1 | d, h |