Table 3.
The list of 13 group of diseases targeted by the enrichment analysis (DAVID 6.7). The analysis includes two tests to assess significance of the genes participating to each disease category (Permutation test P-value and FDR correction). N = number of genes with implication in the categorized disease. % = percentage of representation in the total of 429 genes.
| Disease Category | N | % | P-Value | FDR |
|---|---|---|---|---|
| Metabolic | 167 | 34.9 | 1.80 × 10−3 | 4.60 × 10−3 |
| Cardiovascular | 137 | 28.7 | 4.50 × 10−3 | 1.00 × 10−2 |
| Chemo-dependency | 115 | 24.1 | 1.90 × 10−2 | 2.80 × 10−2 |
| Pharmacogenomic | 109 | 22.8 | 2.40 × 10−6 | 4.30 × 10−5 |
| Neurological | 106 | 22.2 | 1.80 × 10−4 | 8.00 × 10−4 |
| Cancer | 103 | 21.5 | 1.70 × 10−2 | 2.80 × 10−2 |
| Psych | 81 | 16.9 | 4.10 × 10−5 | 2.50 × 10−4 |
| Unknown | 66 | 13.8 | 3.10 × 10−4 | 1.10 × 10−3 |
| Developmental | 60 | 12.6 | 1.10 × 10−3 | 3.40 × 10−3 |
| Other | 58 | 12.1 | 1.10 × 10−2 | 1.90 × 10−2 |
| Renal | 54 | 11.3 | 5.70 × 10−3 | 1.10 × 10−2 |
| Reproduction | 37 | 7.7 | 2.10 × 10−2 | 2.90 × 10−2 |
| Normal-variation | 33 | 6.9 | 7.00 × 10−6 | 6.30 × 10−5 |