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. 2019 Feb;214(2):83–89. doi: 10.1192/bjp.2018.152

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© The Royal College of Psychiatrists 2018

This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http://creativecommons.org/licenses/by-nc-nd-sa/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is included and the original work is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use.

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Fig. 2 — Effect of duration of antipsychotic (upper) or clozapine (lower) treatment on immunoglobulin (Ig)G levels.

A significant negative correlation of duration of clozapine use (years) was observed with an annual reduction in IgG levels of 0.15 g/L (P = 0.03). No correlation was seen with serum IgG level and non-clozapine antipsychotic medications (P = 0.14) despite a longer duration on therapy. Straight lines show predicted IgG at different durations of treatment (in years), based on fitted linear models. Shaded regions display pointwise 95% confidence intervals.