Table 3.

Immunoglobulin concentrations and odds ratio for the clozapine-treated and clozapine-naive groups^a

	Clozapine group	Control group	P
Pre-exclusion cohort, n	123	113
IgG, median	9.31	10.6	<0.0001b
IgA, median	1.58	2.46	<0.0001b
IgM, median	0.61	0.91	<0.0001b
Post-exclusion cohort, n	94	98
IgG, median	9.21	10.6	<0.0001b
IgA, median	1.55	2.46	<0.0001b
IgM, median	0.64	0.91	<0.0001b
Pre-exclusion cohort	OR	(95% CI)
IgG <6.0 g/L	6.00	1.31–27.44	0.0120c
IgA <0.8 g/L	16.75	2.18–128.6	0.0002c
IgM <0.5 g/L	3.26	1.75–6.08	0.0001c
Post-exclusion cohort	OR	(95% CI)
IgG <6.0 g/L	9.02	1.11–73.65	0.0168c
IgA <0.8 g/L	32.63	1.91–558	<0.0001c
IgM <0.5 g/L	2.86	1.42–5.73	0.0040c

^a.Values represent median serum immunoglobulin concentrations in g/L. Reference range for 5th to 95th centiles in healthy adults: IgG, 6.0–16 g/L; IgA, 0.8–4.0 g/L; IgM, 0.5–2.0 g/L.

^b.Mann–Whitney test.

^c.Fisher's exact test.