Table 1.

Characteristics of study sample and predictors of mortality (N = 3374)

Characteristic	N (%)	Hazard ratio (95% CI); P valuea	Hazard ratio (95% CI); P valueb
Gender
Male	1329 (39)	Ref	Ref
Female	2045 (61)	0.72 (0.63–0.82); P < 0.0001	0.62 (0.54–0.72) P < 0.0001
Ethnicity
White British	1841 (55)	Ref	Ref
White other	852 (25)	0.84 (0.72–0.98); P = 0.026	0.80 (0.69–0.94); P = 0.007
Asian	183 (5)	0.47 (0.32–0.69); P < 0.0001	0.50 (0.34–0.73); P < 0.0001
Black	344 (10)	0.97 (0.78–1.21); P = 0.803	0.91 (0.73–1.14); P = 0.424
Mixed and other	154 (5)	0.59 (0.40–0.97); P= 0.008	0.63 (0.43–0.94); P= 0.022
Marital status
Married	1101 (33)	Ref	Ref
Divorced	407 (12)	0.95 (0.76–1.19); P = 0.638	1.21 (0.96–1.52); P= 0.107
Widowed	1239 (37)	1.01 (0.87–1.18); P = 0.856	1.02 (0.86–1.21); P= 0.825
Single	627 (19)	1.12 (0.93–1.35); P= 0.233	1.25 (1.03–1.50); P = 0.022
Age at diagnosis, years
<65	98 (3)	Ref	Ref
66–75	558 (17)	1.78 (0.96–3.32); P= 0.069	2.06 (1.10–3.86); P= 0.024
76–85	1549 (46)	2.65 (1.45–4.82); P= 0.001	3.07 (1.68–5.63); P < 0.0001
>85	1169 (35)	4.50 (2.47–8.19); P < 0.0001	5.47 (3.00–10.03); P < 0.0001
IMD tertiles
Least deprived (1.9–26.6)	1156 (34)	Ref	Ref
Middle (26.7–36.4)	1107 (33)	1.07 (0.91–1.25); P= 0.401	1.13 (0.96–1.33); P= 0.139
Most deprived (36.5–87.8)	1111 (33)	1.17 (1.00–1.36); P= 0.054	1.23 (1.05–1.44); P= 0.012
MMSE tertiles
Least impaired (24–30)	958 (28)	Ref	Ref
Moderate (18–23)	1157 (34)	1.41 (1.19–1.66); P < 0.0001	1.43 (1.21–1.69); P < 0.0001
Most impaired (0–17)	1259 (37)	1.75 (1.49–2.05); P < 0.0001	1.92 (1.62–2.26); P < 0.0001
Depression
No	3127 (93)	Ref	Ref
Yes	247 (7)	0.82 (0.63–1.08); P= 0.154	0.94 (0.71–1.24); P= 0.645
Antidepressant use
No	2321 (69)	Ref	Ref
Yes	1053 (31)	1.01 (0.88–1.17); P= 0.838	1.15 (0.99–1.33); P= 0.059

IMD, Index of Multiple Deprivation; MMSE, Mini-Mental State Examination; Ref, reference value.

^a.Univariable models.

^b.Multivariable model mutually adjusted for all other variables in the table.