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. 2019 Feb 26;20(5):1014. doi: 10.3390/ijms20051014

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Environment of cg04580029 probe. As depicted by Figure 2A,B, cg04580029 (in green) is located on the chromosome 16p13.3 upstream of KREMEN2 gene. (A) shows that cg04580029 is located in a regulatory element, indicated by acetylation of histone 3 on lysine 27 (H3K27Ac peak, in violet). Furthermore, DNase I hypersensitivity peak clusters (black and grey rectangles) reveal the presence of an accessible chromatin zone which is the sign of a transcriptional activity. (B) confirms that cg04580029 is located within a regulatory zone (promoter flank ENSR00000529174, in light red) and shows in addition that 3 base pairs away is located the transcription start site of KREMEN2 gene, p2@KREMEN2.