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. 2019 Mar 7;20(5):1159. doi: 10.3390/ijms20051159

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Association of TBX2 subfamily hypermethylation with clinicopathological features in human LUAD and LUSC. Gene-level methylation β-values in 522 LUADs (two left panels) and 504 LUSCs (two right panels) were propagated from the TCGA and statistically interrogated with pathological stage and tobacco history (ever: lifetime smokers, never: non-smokers). Kruskal-Wallis test was used to statistically examine differences in methylation β-values of the TBX genes by pathological stage. Wilcoxon rank sum test was used to statistically analyze methylation β-values based on tobacco exposure. All statistical analyses and plots were performed and generated using the R language and environment.