Skip to main content
. 2019 Mar 7;24(5):941. doi: 10.3390/molecules24050941

Figure 1.

Figure 1

Schematic representation of SELEX (Systematic Evolution of Ligands by EXponential Enrichment). The starting single-stranded DNA or RNA library (1014~1016 random oligonucleotides) is composed of sequences 20~100 nucleotides in length with a random region in the middle flanked by fixed primer sequences. After incubation with the target of interest, the bound oligonucleotides are partitioned from unbound sequences and amplified by PCR. The resulting enriched DNA pool is used for the next round of selection.