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Flowchart of nanopore-based aptamer assaying. Nanopore sensors can be used to detect aptamer binding and selection in a real-time. Aptamer and target interaction can be detected by measuring the current disruption caused by molecules electrophoretically driven through the pore. (A) An ionic current is passed through the nanopore. The current changes as molecular target (B), aptamer (C), or aptamer–target complex (D) passes through the nanopore.
