Table 1.
Compound | Ki (nM) | |||
---|---|---|---|---|
hCA I | hCA II | hCA IX | hCA XII | |
1 | >10,000 | >10,000 | 32.1 | 5.8 |
2 | >10,000 | >10,000 | 67.5 | 8.5 |
3 | >10,000 | >10,000 | 88.7 | 9.6 |
4 | >10,000 | >10,000 | 32.0 | 6.4 |
5 | >10,000 | >10,000 | 294.9 | 7.1 |
6 | >10,000 | >10,000 | 27.1 | 5.6 |
7 | >10,000 | >10,000 | 114.7 | 7.7 |
8 | >10,000 | >10,000 | 190.3 | 8.9 |
9 | >10,000 | >10,000 | 92.8 | 8.1 |
10 | >10,000 | >10,000 | 162.3 | 9.4 |
11 | >10,000 | >10,000 | 307.7 | 9.6 |
12 | >10,000 | >10,000 | 120.7 | 26.4 |
13 | >10,000 | >10,000 | 76.8 | 8.5 |
AAZ | 250 | 12 | 25 | 5.7 |
* Mean from three different assays, by a stopped flow technique (errors were in the range of ±5–10% of the reported values).