Table 1.
Inhibition data of hCA I, hCA II, hCA IX, hCA XII with compounds here reported and the standard sulfonamide inhibitor acetazolamide (AAZ) by a stopped flow CO2 hydrase assay.
| Compound | Ki (nM) | |||
|---|---|---|---|---|
| hCA I | hCA II | hCA IX | hCA XII | |
| 1 | >10,000 | >10,000 | 32.1 | 5.8 |
| 2 | >10,000 | >10,000 | 67.5 | 8.5 |
| 3 | >10,000 | >10,000 | 88.7 | 9.6 |
| 4 | >10,000 | >10,000 | 32.0 | 6.4 |
| 5 | >10,000 | >10,000 | 294.9 | 7.1 |
| 6 | >10,000 | >10,000 | 27.1 | 5.6 |
| 7 | >10,000 | >10,000 | 114.7 | 7.7 |
| 8 | >10,000 | >10,000 | 190.3 | 8.9 |
| 9 | >10,000 | >10,000 | 92.8 | 8.1 |
| 10 | >10,000 | >10,000 | 162.3 | 9.4 |
| 11 | >10,000 | >10,000 | 307.7 | 9.6 |
| 12 | >10,000 | >10,000 | 120.7 | 26.4 |
| 13 | >10,000 | >10,000 | 76.8 | 8.5 |
| AAZ | 250 | 12 | 25 | 5.7 |
* Mean from three different assays, by a stopped flow technique (errors were in the range of ±5–10% of the reported values).