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Effect of HTHQ on l-DOPA-induced ERK1/2 phosphorylation in PC12 cells. PC12 cells were exposed to 200 µM l-DOPA (A,C) in the presence of 10 µM HTHQ (B,D) for 0.5–6 h. The values of the relative density ratios of ERK1/2 phosphorylation (p-ERK1/2) to total ERK1/2 (t-ERK1/2) are expressed in arbitrary units. The results are expressed as the mean ± S.E.M. (n = 4). * p < 0.05 compared to control level (0 h), # p < 0.05 compared to values at 0.5 and 1 h (ANOVA with post-hoc Tukey’s test).
