Table 3.
Antiviral activities of the test compounds against tobacco mosaic virus (TMV) in vivo at 500 μg/mL.
| Compounds | R1 | R2 | Curative Activity (%) a | Protective Activity (%) a |
|---|---|---|---|---|
| 3a | 4-Cl-Ph | CH3 | 61.2 ± 8.5 | 42.5 ± 1.6 |
| 3b | 4-Cl-Ph | CH2CH3 | 49.6 ± 2.2 | 48.6 ± 1.8 |
| 3c | 4-OCH3-Ph | CH3 | 62.2 ± 8.5 | 42.8 ± 8.5 |
| 3d | 4-OCH3-Ph | CH2CH3 | 35.4 ± 1.7 | 39.1 ± 7.0 |
| 3e | 2-Cl-Ph | CH3 | 52.3 ± 3.7 | 51.9 ± 6.4 |
| 3f | 2-Cl-Ph | CH2CH3 | 28.3 ± 3.6 | 53.7 ± 8.6 |
| 3g | 3-NO2-Ph | CH3 | 49.8 ± 5.4 | 24.8 ± 7.3 |
| 3h | 3-NO2-Ph | CH2CH3 | 51.9 ± 2.2 | 66.7 ± 2.1 |
| 3i | 4-NO2-Ph | CH3 | 50.9 ± 2.0 | 53.6 ± 9.3 |
| 3j | 4-NO2-Ph | CH2CH3 | 20.0 ± 2.3 | 63.8 ± 6.5 |
| 3k | 4-CH3-Ph | CH2CH3 | 55.8 ± 3.2 | 56.7 ± 7.3 |
| 3l | Ph | CH3 | 69.3 ± 8.1 | 45.1 ± 7.3 |
| 3m | Ph | CH2CH3 | 48.1 ± 9.1 | 56.7 ± 6.4 |
| 3n | 4-Br-Ph | CH3 | 44.1 ± 5.5 | 56.3 ± 7.8 |
| 3o | 4-Br-Ph | CH2CH3 | 52.1 ± 8.9 | 49.6 ± 7.4 |
| 3p | 3-CF3-Ph | CH3 | 34.3 ± 9.1 | 58.8 ± 2.4 |
| 3q | 3-CF3-Ph | CH2CH3 | 51.7 ± 3.9 | 55.8 ± 9.3 |
| 3r | 3-CH3-Ph | CH3 | 50.7 ± 2.1 | 55.7 ± 9.5 |
| 3s | 3-CH3-Ph | CH2CH3 | 63.4 ± 1.7 | 55.4 ± 5.5 |
| Ningnanmycin b | - | - | 56.1 ± 2.5 | 56.2 ± 6.4 |
a Average of three replicates. b The commercial antiviral agent, ningnanmycin.