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Deregulation of autophagy during Dengue virus infection. During DENV infection, autophagy has pro-viral activity. The induction of autophagy by DENV (1) upregulates autophagosomes formation (2) that fuse with endosomes to form amphisomes (3), virus-induced compartments in which DENV actively replicates (4). Accumulating autophagosomes stimulate lipid metabolism (5) leading to the liberation of fatty acids and energy to sustain viral replication (6).
