Figure 2.

Key manuscripts and associated breakthrough technologies that contributed to demonstrating that a specific ribosome composition determines the subset of mRNAs being translated. First and second decades, 1999–2008 and 2009–2018, are depicted by two grey arrays. Hallmarks colors are as follows: impact of RP defects (green) and rRNA modifications (orange) on ribosome translational activity, as well as breakthrough technologies and ribosome structure provided by recently developed structural technologies (blue).