Figure 7.

Preventive effects of an intracerebroventricular injection of G2-β-CD on body weight loss (A) and Purkinje cell loss in the cerebellum (B and C) of Npc1^−/− mice. An injection of G2-β-CD 21.4 µmol/kg was performed in mice at 4 weeks of age. The body weight was measured once a week until histological analysis. A brain sample was collected at 8 weeks and 2 days of age and immunohistochemical staining of calbindin was performed. The representative pictures were shown (B). Scale bar: 100 μm. The number of calbindin-positive cells was measured (C). Each point and bar represents the mean ± S.E.M. (n = 5–6). ** p < 0.01 compared with the saline group.