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Sequencing analyses of the TP53 gene reveal the emergence of a new TP53 mutation, D281G, in MV4-11-R. (A) The R248W (CGG → TGG, red frame) TP53 mutation was detected in MV4-11-P, while both R248W and D281G (GAC → GGC, red frame) mutations were observed in MV4-11-R using Sanger sequencing analysis. (B) The percentage of mutant antisense-alleles for D281G and R248W mutations in MV4-11-P and MV4-11-R was determined by pyrosequencing.
