Figure 3.

A core set of genes with switches between isoform expression over time is common to the cell lines analysed (A) We detected an intersection of 89 genes for the three cell lines, for the genes for which switching in isoform expression was detected in our analysis. (B) The top enriched pathways for the 89 genes are mRNA splicing and translation, as well as the processing of capped intron-containing pre-mRNA. (C) All but one of the top 10 enriched disease ontology terms associated with the 89 genes are different forms of cancer. (D) We analysed all genes for which switches in isoform expression over time were detected for the three cell lines. A set of common pathways including mRNA splicing, translation and ribosomal activity was identified for all cell lines, the L-1236 cell line shows an additional enrichment for the FGFR2 pathway.