Scheme 4.
Synthesis of compounds 14a–g. Reagents and conditions: (a) K2CO3, DMF, corresponding substituted reagent; (b) methanesulfonyl chloride, DIPEA, Py; (c) LiOH, MeOH, H2O, 30 °C; (d) NH2NH2·H2O, EtOH, reflux.
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