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Inhibition activity of compounds 9a–q towards PGAM1.
| Compound | R 3 | PGAM1 IC50 (μM) 1 |
|---|---|---|
| 9a |
|
0.54 ± 0.04 |
| 9b |
|
0.47 ± 0.08 |
| 9c |
|
0.90 ± 0.07 |
| 9d |
|
2.2 ± 0.5 |
| 9e |
|
0.61 ± 0.12 |
| 9f |
|
0.54 ± 0.07 |
| 9g |
|
0.79 ± 0.04 |
| 9h |
|
0.89 ± 0.13 |
| 9i |
|
0.27 ± 0.04 |
| 9j |
|
0.28 ± 0.07 |
| 9k |
|
0.89 ± 0.33 |
| 9l |
|
0.90 ± 0.26 |
| 9m |
|
0.26 ± 0.02 |
| 9n |
|
0.20 ± 0.04 |
| 9o |
|
0.35 ± 0.005 |
| 9p |
|
0.47 ± 0.07 |
| 9q |
|
0.26 ± 0.03 |
1 The data are presented as mean ± s.d. (n = 3).
