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Schematic illustration of long-term tumor targeting and bioimaging mediated by PPG-cRGD NPs. (A) Synthesis scheme of PPG-cRGD NPs. (B) Tumor homing of intravenously injected PPG-cRGD NPs through RGD-mediated binding to tumor endothelial cells. Intratumorally accumulated PPG-cRGD NPs elicit enhanced intracellular uptake due to specific binding of PPG-cRGD NPs on αvβ3 integrin receptor in tumor cells, resulting in long-term tumor targeting and bioimaging.
