Table 3.
Overview of the putative pigmentation-relevant therapeutic potential of cutaneous cannabinoid signaling.
| Disease | Intervention | Level of Evidence | References |
|---|---|---|---|
| Hypopigmentation | Elevation of the eCB-tone/activation of CB1 (?) | In vitro (monoculture of primary human epidermal melanocytes) | [155] |
| Administration of CBD (via activating CB1) | In vitro (monoculture of primary human epidermal melanocytes) | [60] | |
| Hyperpigmentation | Elevation of the eCB-tone/activation of CB1 (?) | In vitro (co-culture of SK-mel-1 and HaCaT keratinocytes) | [160] |
| β-caryophyllene | In vitro (mono-culture of B16 melanoma cells) | [158] | |
| Vitiligo | Elevation of the eCB-tone 1 | Hypothesis based on literature data | [164,165,166,167] |
1 Note that well-controlled studies proving the efficiency of cannabinoids are missing; however, in light of the available data, elevation of the eCB-tone might exert beneficial effects in vitiligo, therefore it deserves systematic experimental exploration.