Figure 1.

Effect of chemerin on the metabolic status of different organs (inconclusive results indicated by reverse arrows). Data published so far mostly agree that chemerin impairs skeletal muscle insulin response. This was not observed in the liver, here gluconeogenesis was enhanced in chemerin deficient mice. The function of chemerin on blood pressure was modified by gender. Chemerin further stimulated angiogenesis and vascular inflammation. Adipose tissue weight was not changed by chemerin. This adipokine may even improve insulin response of fat tissue although the number of adipose tissue resident macrophages was increased. Stimulatory and inhibitory effects of chemerin on glucose-induced release of insulin by pancreatic beta-cells was reported. Inconclusive findings may be partly explained by the different models studied.