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. 2019 Mar 3;20(5):1087. doi: 10.3390/ijms20051087

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Summary of Resveratrol effects on ER dependent pathways. 1. RSV represses different classes of oestrogen up-regulated genes in breast cancer cells. 2. RSV activates p38 MAPK/CK2 signalling, induces the recruitment of a p53/NFY complex at the ERα proximal promoter reducing ER mRNA and protein levels in tamoxifen-resistant breast cancer cells. 3. RSV induces NRF2-regulated antioxidant genes and inhibits E2-mediated alterations in NRF2 promoter methylation in mammary cells. 4. RSV inhibits the ER-dependent PI3K activity in MCF-7 breast cancer cells. 5. RSV inhibits the cross-talk between ER and IGF-1R signalling in ovarian cancer cells.