Table 1. In Vitro Inhibitory Profile of Rodin Compounds, CI-994, and Cpd-60a.
| IC50 (μM) |
||||||
|---|---|---|---|---|---|---|
| target | Rodin-A | Rodin-B | Rodin-C | Rodin-D | CI-994 | Cpd-60 |
| HDAC1 | 0.15 | 0.27 | 0.059 | 0.12 | 0.62 | 0.008 |
| HDAC2 | 0.43 | 0.28 | 0.18 | 0.28 | 0.54 | 0.031 |
| HDAC3 | >30 | 27.6 | 20.2 | >30 | 0.28 | 2.59 |
| HDAC4 | >30 | >30 | >30 | >30 | >30 | >30 |
| HDAC5 | >30 | >30 | >30 | >30 | >30 | >30 |
| HDAC6 | >30 | >30 | >30 | >30 | >30 | >30 |
| HDAC7 | >30 | >30 | >30 | >30 | >30 | >30 |
| HDAC8 | >30 | >30 | >30 | >30 | >30 | >30 |
| HDAC9 | >30 | >30 | >30 | >30 | >30 | >30 |
| HDAC10 | >30 | >30 | >30 | >30 | 8.95 | >30 |
| HDAC11 | >30 | >30 | 5.39 | 11.8 | >30 | 5.79 |
a
Inhibitory activity of Rodin-A, Rodin-B, Rodin-C, Rodin-D, CI-994, and Cpd-60 toward deacetylase activity of HDAC isoforms 1–11 (N ≥ 3).