Table 2.
Geometric mean MFs 1 of six CDMs in IDCs and by subtype.
| Mutation | HR+/HER2+ (n = 20) |
HR+/HER2− (n = 20) |
HR−/HER2+ (n = 21) |
HR−/HER2− (TNBC) (n = 20) |
All IDCs |
|---|---|---|---|---|---|
| PIK3CA H1047R | 1.32 × 10−5 | 1.20 × 10−5 | 2.15 × 10−5 | 7.64 × 10−7 | 7.23 × 10−6 |
| PIK3CA E545K | 3.66 × 10−5 | 2.29 × 10−5 | 7.94 × 10−6 | 1.68 × 10−5 | 1.81 × 10−5 |
| KRAS G12D | 1.79 × 10−5 | 7.43 × 10−6 | 3.47 × 10−5 | 1.18 × 10−5 | 1.55 × 10−5 |
| KRAS G12V | 1.80 × 10−6 | 3.05 × 10−7 | 3.57 × 10−6 | 8.57 × 10−7 | 1.15 × 10−6 |
| HRAS G12D | 2.09 × 10−5 | 3.59 × 10−5 | 2.54 × 10−5 | 3.34 × 10−5 | 2.82 × 10−5 |
| BRAF V600E | 1.19 × 10−5 | 4.84 × 10−5 | 1.19 × 10−5 | 1.96 × 10−5 | 1.90 × 10−5 |
1 Geometric mean MFs were calculated using all MF measurements extrapolated from pixel intensities and standard curves, including measurements below the limit of accurate ACB-PCR quantification (1 × 10−5). Subtype geometric mean MFs greater than the limit of accurate ACB-PCR quantification are shown in bold. IDCs: invasive ductal carcinomas.