Figure 10.

Fabrication, morphology, and mechanism of side-by-side structures. (A) Side-by-side electrospinning process: (a) experimental apparatus (inset: connection of side-by-side spinneret with the working fluids and power supply); (b) a photograph of a typical side-by-side electrospinning process with the Teflon-coated spinneret; (c) a Janus Taylor cone formed with the Teflon-coated spinneret; (d) fiber mat from side-by-side electrospinning with uncoated side-by-side spinneret; (e) the separation of fluids when using the uncoated spinneret; (f) an illustration of the role played by the Teflon coating: A—the separation of fluids arising from repulsive forces Ft (between the two Taylor cones), Fs (between the two straight fluid jets). (B) TEM images of (a) F3; (b) F4; (c) F5; (d) F6 and Fc (between the two coils); and B—the formation of an integrated Janus Taylor cone with the Teflon coating. (C) Field emission scanning electron microscope (FESEM) images of the fibers remaining after 24 h of dissolution and the proposed drug release mechanism. (a–d) show the remains of fibers F3–F6 respectively; (D) is a schematic diagram explaining the mechanism of drug release from the Janus fibers. Reproduced from [236] with permission from Elsevier Ltd.; Copyright 2016.